By Topic

Comparison between Acoustic Radiation Force Impulse (ARFI)-based hepatic stiffness quantification in deformed and undeformed pressurized canine livers

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$33 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

5 Author(s)
Veronica Rotemberg ; Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708-0281, USA ; Mark L Palmeri ; Ned C Rouze ; Roger Nightingale
more authors

Increased hepatic interstitial pressure can be observed in patients with advanced liver disease and is associated with worsened clinical outcomes. Elevated hepatic stiffness has been reported clinically with increases in hepatic venous pressure gradient (HVPG). An experiment was designed to determine whether stiffness increase exhibited with hepatic pressurization results from a strain-dependent hyperelastic behavior. Six excised canine livers were subjected to variations in interstitial pressure through cannulation of the portal vein and closure of the hepatic artery and hepatic vein under constrained conditions (in which the liver was not free to expand) and unconstrained conditions. Radiation force derived shear wave speed estimates were obtained and correlated with pressure. Estimates of hepatic shear stiffness increased with changes in interstitial pressure over a physiologically relevant range of pressures (0-35mmHg) from 1.5 to 3.5 m/s. These increases were observed only under conditions in which the liver was free to expand while pressurized.

Published in:

2011 IEEE International Ultrasonics Symposium

Date of Conference:

18-21 Oct. 2011