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The contaminant source estimation problem is getting increasing importance due to more and more occurrences of sick building syndrome and attacks from covert chemical warfare agents. To monitor a building contamination condition, a number of sensors are connected through a network, and the sensor measurements are sent to a fusion center to estimate contaminant source information. An estimation algorithm is required such that timely actions can be taken to mitigate the adverse effects. This paper proposes a multiple model unscented Kalman filter (MM-UKF) to estimate the contaminant source location, the source emission rate and the release time. A simulation test is conducted on a computer generated three-story building. The results show that the MM-UKF algorithm can achieve real-time estimation.