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The Tenth IEEE International Symposium on Parallel and Distributed Processing with Applications (ISPA 2012) was held in Leganes, Spain, July 10-13 2012. ISPA 2012 is the next event in a series of highly successful symposia on parallel and distributed computing and networking, previously held as ISPA 2011 (Busan, Korea), ISPA 2010 (Taipei, Taiwan), ISPA 2009 (Chengdu, China), ISPA 2008 (Sydney, Australia), ISPA 2007 (Niagara Falls, Canada), ISPA 2006 (Sorrento, Italy), ISPA 2005 (Nanjing, China), ISPA 2004 (Hong Kong), and ISPA 2003 (Aizu, Japan). This year the value, breadth, and depth of the ISPA symposium continues to strengthen and grow in importance for both the academic and industrial communities. This strength is evidenced this year by having a high number of submissions resulting in a selective program. In addition, the publishing of special issues from several high quality journals from Elsevier, Springer and Oxford make this symposium stronger.