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Retention of Features on a Mapped Drosophila Brain Surface Using a Bézier-Tube-Based Surface Model Averaging Technique

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6 Author(s)
Guan-Yu Chen ; Dept. of Electr. Eng., Nat. Tsing Hua Univ., Hsinchu, Taiwan ; Cheng-Chi Wu ; Hao-Chiang Shao ; Hsiu-Ming Chang
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Model averaging is a widely used technique in biomedical applications. Two established model averaging methods, iterative shape averaging (ISA) method and virtual insect brain (VIB) method, have been applied to several organisms to generate average representations of their brain surfaces. However, without sufficient samples, some features of the average Drosophila brain surface obtained using the above methods may disappear or become distorted. To overcome this problem, we propose a Bézier-tube-based surface model averaging strategy. The proposed method first compensates for disparities in position, orientation, and dimension of input surfaces, and then evaluates the average surface by performing shape-based interpolation. Structural features with larger individual disparities are simplified with half-ellipse-shaped Bézier tubes, and are unified according to these tubes to avoid distortion during the averaging process. Experimental results show that the average model yielded by our method could preserve fine features and avoid structural distortions even if only a limit amount of input samples are used. Finally, we qualitatively compare our results with those obtained by ISA and VIB methods by measuring the surface-to-surface distances between input surfaces and the averaged ones. The comparisons show that the proposed method could generate a more representative average surface than both ISA and VIB methods.

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Biomedical Engineering, IEEE Transactions on  (Volume:59 ,  Issue: 12 )