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Adaptivity is a key feature of service-based systems to fully exploit the advantages offered by the service paradigm. In this paper we present a comprehensive framework that can be used to define and support highly adaptable context-aware service-based business processes. In our approach, all the adaptation-related tasks, from detecting an adaptation problem to finding a solution and applying it to a running process instance, are performed automatically at run time. We also show how the framework has been implemented and applied to a real-world scenario from the logistics domain.