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This paper proposes and designs a novel human vital signals monitor system based on wireless sensor network. It can realize the real-time measurement of multi-points and multi-signals at the same time. This system adopts RF controller CC2510 as the control core and SimpliciTI protocol to set up wireless network. After gathering the signals of temperature, heart rate and blood pressure, the terminal devices send the data to the processing center to establish intelligent database resources. The practical experiment shows that the system has advantages on reliability, flexibility and low cost. It has a broad application prospect in clinic nursing and miner protection.