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Simultaneous quantitative detection of tetracyclines derivatives by raman spectroscopy

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5 Author(s)
Xiaoyun Chen ; Dept. of Biomed. Eng., Tianjin Univ., Tianjin, China ; Weizi Liang ; Chunmei Yang ; Wang Lin
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Our work was to develop a methodology to qualitatively and quantitatively detect tetracyclines (TCs) derivatives, such as doxycycline (DOTC) and oxytetracycline (OTC). The Raman spectra region of 500-1800 cm-1 reveals distinctive spectra features of TCs. We applied principal component analysis (PCA) to investigate the antibiotics composition from Raman spectra. The capability of the model was evaluated by partial least square analysis (PLS) with a leave-one-out-cross-validation method. The result shows the feasibility of simultaneous quantitative detection of tetracycline derivatives by portable Raman spectroscopy.

Published in:

Virtual Environments Human-Computer Interfaces and Measurement Systems (VECIMS), 2012 IEEE International Conference on

Date of Conference:

2-4 July 2012