By Topic

Low-cost and ultra-sensitive poly-Si nanowire biosensor for Hepatitis B Virus (HBV) DNA detection

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

7 Author(s)

Based on the improvements of the fabrication technologies, the dimension of the device has decreased to tens of nanometer. This scale approaches to most bio-molecules, such as DNAs and proteins. Therefore, the nano-scale device has become an important connection between semiconductor technologies and biomedical applications. However, few of previous studies consider the feasibility to integrate standard CMOS chip with biomolecular detections. In this work, we demonstrated a Hepatitis B Virus (HBV) DNA detection sensor with CMOS-compatible poly-silicon nanowire devices. The developed biosensor shows the detection limit with 100fM and the capability to distinguish 1 base-pair mismatched DNA. In addition, the design concept of this biosensor has been implemented in DNA biomolecular detection SoC by a commercialized 0.35μm TSMC process. This work demonstrated the potential of CMOS technologies in biomedical applications.

Published in:

Circuits and Systems (ISCAS), 2012 IEEE International Symposium on

Date of Conference:

20-23 May 2012