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In this paper first we present an overview of the state-of-the-art remote patient monitoring systems in the backdrop of real clinical needs. The paper establishes a clear guideline in terms of clinical expectations from such a system from the viewpoint of practicing clinicians. It provides in-depth analysis of the shortcomings of the existing architectures and paves a way towards developing a practical “patient-centric” architecture that could be useful in the day-to-day clinical practice for providing “continuum of care”. Subsequently, the restrictions imposed by the resource constrained nature of such a system on development of appropriate hardware for supporting information processing on the data acquired by body-worn sensors are analyzed.