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This paper presents an overview of the new developments carried out to offer a reliable and efficient support for different computing infrastructures in the Kepler workflow orchestration system. The aim of the work is to help scientists to transparently use these infrastructures regardless of the underlying middleware. We introduce new complex workflow scenarios developed in the context of the EU EGI Inspire project and their exploitation by two nuclear fusion applications. The presented use cases represent typical scenarios which are common also in other fields and could be easily reused for other applications.