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A flexible biomedical visualization framework implemented with Java, OpenGL, and OpenCL performs efficient volume rendering with large, multi-modal datasets. The framework takes advantage of the parallel processing power on modern graphics hardware with novel OpenCL and GLSL shading language implementations. The Java and GPU environment provide portable advanced biomedical image visualization applications. Several applications built on top of the GPU framework are also presented to show the extensibility of the application. These include multi-surface rendering, stereoscopic rendering, image fusion, and diffusion tensor visualization.