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This paper presents a method to ascertain related bioactivity mediums of silica-reduced pulmonary fibrosis in rats, to construct the regulator network of the material bioactivity and its genes, to evaluation network adjustment mechanism of silicosis fibrosis systematically. The adjustment network can be regarded as a context-sensitive knowledge graph (with fuzzy weighted edges among nodes). In order to model the fuzzy knowledge within the constructed adjustment network, we adopt Dimensional Ontology (DO), which is a context-sensitive knowledge framework based on Semantic Web technologies. The DO based Adjustment network can be used in related future research.