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Optimization of multimedia transmissions over wireless channels should be aimed at maximizing the video quality perceived by the final user. For transmission of video sequences over an orthogonal frequency division multiplexing (OFDM) system in a slowly varying Rayleigh faded environment, we develop a cross-layer technique, based on a slice loss visibility (SLV) model used to evaluate the visual importance of each slice. In particular, taking into account the visibility scores available from the bitstream, depending on the scenario, we optimize the mapping of video slices within a 2-D time-frequency resource block and/or the channel code rates, in order to better protect more visually important slices. The proposed algorithm is investigated for several scenarios, with different levels of information about the channel available in the optimization process. Results demonstrate that, for different physical environments and different video sequences, the proposed algorithm outperforms baseline ones which do not take into account either the SLV or the CSI in the video transmission.