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By introducing signaling and self-management in a Turing node and a signaling network as an overlay over the computing network, the current von-Neumann computing model is evolved to bring the architectural resiliency of cellular organisms to computing infrastructure. The DIME computing model introduces the genetic transactions of replication, repair, recombination and reconfiguration to program self-resiliency in distributed computing systems executing a managed workflow. The injection of parallelism and network based composition of "Self" identity are the first steps in introducing the elements of homeostasis and self-management in the computing infrastructure. DIMEs inject the architectural resiliency of cellular organisms to create a new class of distributed autonomic computing systems using managed Turing machine networks.