Scheduled System Maintenance:
On Monday, April 27th, IEEE Xplore will undergo scheduled maintenance from 1:00 PM - 3:00 PM ET (17:00 - 19:00 UTC). No interruption in service is anticipated.
By Topic

Antidepression of Ping Yu Formula via the Regulation of cAMP Signaling Pathway

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

3 Author(s)
Huan Xiang ; Phys. Educ. Dept., Shanxi Univ. Taiyuan, Taiyuan, China ; Jun-sheng Tian ; Zuo-guang Zhang

The study is aiming to investigate the anti-depression effect and possible mechanism of Pingyu Formula (Pingyu), which is an herbal supplement derived from Chinese Traditional Medicine. Tail suspension test (TST) and forced swimming test (FST) were used to investigate the anti-depression effect. The cyclic AMP (cAMP) levels, CREB and BDNF mRNA expression in rats' hippocampi were investigated via ELISA or RT-PCR method respectively. The results showed that Pingyu (75.0, 150 mg/kg, p.o.) reduced the duration of immobility in the FST and TST significantly, while the locomotor activity was not affected. Furthermore, the cAMP level was significantly increased after the treatment of Pingyu (50.0 mg/kg, p.o.) compared with the control group. Levels of the CREB-1, CREB-2 and BDNF mRNA expression were also increased after treatment of Pingyu. In summary, a possible pharmacological mechanism on anti-depression effect of Pingyu was related to the regulation of cAMP signaling pathway.

Published in:

Biomedical Engineering and Biotechnology (iCBEB), 2012 International Conference on

Date of Conference:

28-30 May 2012