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This paper presents an indirect adaptive method to solve the fault-tolerant control (FTC) problem against actuator failures for large scale systems. The adaptation laws are proposed to estimate unknown eventual faults on actuators, and also to estimate unknown constant external disturbances on-line. Then a class of distributed state feedback controllers are constructed for automatically compensating the fault effects on systems based on the information from adaptive scheme. On the basis of Lyapunov stability theory, it is shows that the resulting adaptive closed-loop large-scale system can be guaranteed the asymptotic stability even in the cases of faults in actuators and disturbances. The proposed design technique is finally evaluated in the light of a simulation example.