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A fully integrated hepatitis B virus DNA detection SoC based on monolithic polysilicon nanowire CMOS process

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14 Author(s)
Che-Wei Huang ; National Taiwan University, Taipei, Taiwan ; Yu-Jie Huang ; Pei-Wen Yen ; Hsiao-Ting Hsueh
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Polysilicon nanowire (poly-Si NW) based biosensor is integrated with the wireless acquisition circuits in a standard CMOS SoC for the first time. To improve detection quality, a chopper DDA-based analog front-end with features of low noise, high CMRR, and rail-to-rail input range is implemented. Additional temperature sensor is also included to compensate temperature drift of the biosensor. The results indicate that the detection limit is as low as 10fM. The capability to distinguish one base-pair mismatched DNAs is also demonstrated.

Published in:

2012 Symposium on VLSI Circuits (VLSIC)

Date of Conference:

13-15 June 2012