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Stochastic optical active rheology

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5 Author(s)
Lee, Hyungsuk ; School of Mechanical Engineering, Yonsei University, Seoul, Korea ; Shin, Yongdae ; Kim, Sun Taek ; Reinherz, E.L.
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Your organization might have access to this article on the publisher's site. To check, click on this link:http://dx.doi.org/+10.1063/1.4737159 

We demonstrate a stochastic based method for performing active rheology using optical tweezers. By monitoring the displacement of an embedded particle in response to stochastic optical forces, a rapid estimate of the frequency dependent shear moduli of a sample is achieved in the range of 10-1–103 Hz. We utilize the method to probe linear viscoelastic properties of hydrogels at varied cross-linker concentrations. Combined with fluorescence imaging, our method demonstrates non-linear changes of bond strength between T cell receptors and an antigenic peptide due to force-induced cell activation.

Published in:

Applied Physics Letters  (Volume:101 ,  Issue: 3 )

Date of Publication:

Jul 2012

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