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Optical multispectral imaging during open neurosurgery can provide functional information equivalent to fMRI as well as information about blood flow and oxygenation dynamics. To perform multispectral analysis images acquired sequentially under different illumination wavelengths must be coregistered such that information about the same surface region can be obtained throughout the imaging time period. In this paper, we present a feature driven registration technique that can register multispectral images and is robust to specular reflections and to the variable appearance of the brain's surface under different illumination conditions. We present preliminary results on data from two patients.