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Microwave ablation computational model, on COMSOL Multiphysics 4.0a, was presented in this paper using two types of coaxial antenna, one-slot and two-slot antenna. Computational model was done using electric and thermal properties of healthy breast tissue and tumoral breast tissue. Maximum temperature reached with two-slot coaxial antenna on healthy breast tissue was 110 °C, and on tumoral breast tissue was 141 °C. One-slot coaxial antenna model got maximum temperature of 120 °C on healthy tissue and 137 °C on tumoral tissue. Better results were achieved for two-slot coaxial antenna.