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Micro-channel cooling is gaining considerable attention as an alternative technique for cooling of High-Energy Physics (HEP) detectors and Front-End (FE) electronics. This technology is being evaluated for future tracking devices, where material budget limitations are a major concern. It has been approved as the baseline for the local thermal management of the NA62 GigaTracKer (GTK) silicon pixel detector, where a micro-fabricated silicon cooling plate would stand directly in the beam. Other possible applications are also being studied in the context of detectors upgrades for the CERN Large Hadron Collider (LHC). In this paper, the current status of this R&D at CERN is presented.