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A planar-type leakage current and impedance microsensor for detection of interaction between electrolyte-entrapping liposome and protein

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6 Author(s)
Ohara, Y. ; Grad. Sch. of Sci. & Technol., Kyoto Inst. of Technol., Kyoto, Japan ; Lorchirachoonkul, P. ; Yamashita, K. ; Noda, M.
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We have developed a new leakage current microsensor by using simpler planar processes than Si-surface-bulk micromachining processes used in the previous microwell structure. This sensor fabrication and structure can easily make a target solution volume smaller than μL with excellent immobilization of the droplet and intact biomolecules as sensing elements, as a result, reduce effectively the background noise current in the microsensor and improve reproducibility of the results. The leakage current due to the biochemical interaction was successfully evaluated. Cole-Cole plots from the impedance analysis also show quantitative difference between with and without the interaction, depending on the charge-transfer impedance.

Published in:

Future of Electron Devices, Kansai (IMFEDK), 2012 IEEE International Meeting for

Date of Conference:

9-11 May 2012