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A single-ended transmitter (Tx) is proposed to compensate for the crosstalk-induced jitter (CIJ) of coupled microstrip lines by subtracting a mimicked crosstalk waveform from data signal at Tx during the data transition time, depending on the data transition of an adjacent line. Since the CIJ component is proportional to the time derivative of data signal, the mimicked crosstalk waveform subtracted at Tx cancels the CIJ at receiver (Rx) for the linearly changing data signal with time. As a by-product, this scheme reduces ISI at Rx. The Tx chip in a 0.13-μm CMOS process reduces the total Rx jitter by 96 ps (69%) at 7.2 Gbps (4-in channels) and by 120 ps (72%) at 6 Gbps (8-in channels).