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Quantitative imaging of red blood cell velocity invivo using optical coherence Doppler tomography

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5 Author(s)
Hugang Ren ; Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York 11794, USA ; Congwu Du ; Park, Kicheon ; Volkow, N.D.
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We present particle counting ultrahigh-resolution optical Doppler tomography (pc-μODT) that enables accurate imaging of red blood cell velocities (νRBC) of cerebrovascular networks by detecting the Doppler phase transients induced by the passage of a RBC through a capillary. We apply pc-μODT to image the response of capillary νRBC to mild hypercapnia in mouse cortex. The results show that νRBC in normocapnia (νN = 0.72 ± 0.15 mm/s) increased 36.1% ± 5.3% (νH = 0.98 ± 0.29 mm/s) in response to hypercapnia. Due to uncorrected angle effect and low hematocrit (e.g., ∼10%), νRBC directly measured by μODT were markedly underestimated (νN ≈ 0.27 ± 0.03 mm/s, νH ≈ 0.37± 0.05 mm/s). Nevertheless, the measured νRBC increase (35.3%) matched that (36.1% ± 5.3%) by pc-μODT.

Published in:

Applied Physics Letters  (Volume:100 ,  Issue: 23 )

Date of Publication:

Jun 2012

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