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This paper studies the prevention of premature failures of LED backlights used in mobile devices that are subject to different use conditions. This is a vitally important topic for consumer mobile device manufacturers as the life expectancy of two identical devices from the same production line may vary substantially under different operating environments and use conditions. These differences are not addressed by traditional reliability assessment methods documented in many electronics handbooks. The paper outlines the use of a prognostics approach and condition-based monitoring for optimizing the reliability in the LED backlight display unit of mobile devices.