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Eigengene extracted by independent component analysis (ICA) is one kind of effective feature for tumor classification. In this letter, a novel tumor classification approach is proposed by using eigengene and support vector machine (SVM) based classifier committee learning (CCL) algorithm. In this method, a strategy of random feature subspace division is designed to improve the diversity of weaker classifiers. Gene expression data constructed by different feature subspaces are modeled by ICA, respectively. And the corresponding eigengene sets extracted by the ICA algorithm are used as the inputs of the weaker SVM classifiers. Moreover, a strategy of Bayesian sum rule (BSR) is designed to integrate the outputs of the weaker SVM classifiers, and used to provide a final decision for the tumor category. Experimental results on three DNA microarray datasets demonstrate that the proposed method is effective and feasible for tumor classification.
Date of Publication: Aug. 2012