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In this paper, we present a new method for localizing the position of the heart from Cine MRI images. This method depends on calculating the summation of the difference between images of a specific slice that we work on it, then applying thresholding on the resulting image to get the region of interest. To validate our method, we compare between our results and results of another method used in localizing the position of the heart which depends on the standard deviation. We worked on images of 14 different patients, come from STACOM database. We achieved by this method good results in determining the position of the heart. This method has different advantages like: it works on different contrast images, fast, and fully automatic.