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We report on a spatially resolved resonant waveguide grating imager for cell cluster analysis under physiological condition. Compared to results obtained under ambient condition, the activation of a receptor resulted in a similar biosensor signature but with faster kinetics and greater amplitude. The imager further detected receptor signaling in and movements of single cells within small cell clusters. This opens possibility to investigate the heterogeneity and robustness of receptor signaling from single cells to cell systems.