By Topic

Poly(caprolactone) shape memory scaffold for bone tissue engineering

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$33 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

3 Author(s)
R. M. Baker ; Biomedical and Chemical Engineering and Syracuse Biomaterials Institute, Syracuse University, Syracuse, New York 13244, USA ; J. H. Henderson ; P. T. Mather

Using synthetic scaffolds as a vessel for bone tissue engineering is a promising technique that could address current limitations associated with autologous grafts, such as donor site scarcity and morbidity. In this study, we aimed to synthesize a biocompatible scaffold with controllable pore morphology that could be used to fill critical size defects through the shape memory effect. To achieve this goal we used a porogen-leaching technique in which a shape memory poly(caprolactone) (PCL) was cured in the presence of salt particles, which were subsequently removed to create high porosity in the scaffold. The overall shape memory behavior of the scaffold was investigated and it was found that the material exhibited greater than 99 % shape fixing and 93 % shape recovery. Preliminary cell culture studies on a non-triggered scaffold showed that cells readily attached to the material and remained viable within the scaffold.

Published in:

2012 38th Annual Northeast Bioengineering Conference (NEBEC)

Date of Conference:

16-18 March 2012