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Micro-Electro-Mechanical Systems (MEMS) technologies demonstrate the potential for applications in the field of tissue engineering, regenerative medicine, and life sciences. The development of a successful model would require investigations of the targeted organ. Computer tomography (CT) and magnetic resonance imaging (MRI) allow for biomodeling of the targeted organ. The Digital Micro-mirroring Microfabrication system (DMM) would utilize its dynamic micro mirrors to fabricate the developed tissue construct according to its desire design and characteristics. The DMM has the capabilities to fabricate many advantageous devices, amongst them; microfluidics systems have the most tissue engineering, regenerative medicine, and life sciences applications to develop in vitro tissue models. Unlike many microfabrication techniques and or devices available to fabricate tissue model, this system eliminates the need for mask by incorporating a dynamic maskless fabrication technique. Since the system can develop models on a micro-scale level, this would make many investigation more economic; requiring less reagents, cells, and above all; it will allow for consistency in experimental analysis to due limited interactions with the end user.