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Nanomechanical DNA origami devices as versatile molecular sensors

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9 Author(s)
Kuzuya, A. ; Dept. of Chem. & Mater. Eng., Kansai Univ., Suita, Japan ; Yamazaki, T. ; Yasuda, K. ; Sakai, Y.
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We propose versatile sensing systems for a variety of chemical and biological targets at molecular resolution. We have designed functional nanomechanical DNA origami devices that can be used as “single-molecule beacons”, which consist of two levers approximately 170 nm long connected at a fulcrum. Various single-molecule inorganic/organic targets ranging from metal ions to proteins as well as a unique binding event of a nucleic acid analogue can be visually detected on AFM by a shape transition of the origami devices.

Published in:

Nano/Micro Engineered and Molecular Systems (NEMS), 2012 7th IEEE International Conference on

Date of Conference:

5-8 March 2012