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The microwave sensing of DNA hybridization using carbon nanotubes decorated with gold nanoislands

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5 Author(s)
Cismaru, Alina ; National Institute for Research and Development in Microtechnology (IMT), P.O. Box 38-160, 023573 Bucharest, Romania ; Dragoman, Mircea ; Radoi, Antonio ; Dinescu, A.
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The hybridization of the deoxyribonucleic acid (DNA) is detected with the help of electromagnetic band gap resonator. The resonance frequency of the unloaded resonator f0=16.07 GHz is shifted to the left at 11.49 GHz when the resonator is loaded with single-stranded DNA anchored to gold nanoislands decorating bamboo-shaped carbon nanotubes deposited on the resonator. Further, single stranded DNA is hybridized and the resonator frequency is shifted to 14.16 GHz for double-stranded DNA. So, the frequency span of the two DNA states are separated by a span of 2.6 GHz in the band 11.5-16.07 GHz due to the very different electrical permittivity values of single- and double-stranded DNA. Thus, the hybridization of DNA is detected unambiguously.

Published in:

Journal of Applied Physics  (Volume:111 ,  Issue: 7 )