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A controlled biochemical release device with embedded nanofluidic channels

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3 Author(s)
Yang, Haifeng ; Department of Electrical and Computer Engineering, Iowa State University, Ames, Iowa 50011, USA ; Hong, Wei ; Dong, Liang

Your organization might have access to this article on the publisher's site. To check, click on this link:http://dx.doi.org/+10.1063/1.4704143 

A controlled release device is developed by embedding nanofluidic biomolecule reservoirs into a polymer network of a stimuli-responsive hydrogel. The reservoirs are made of liquid core-polymer shell nanofibers using co-electrospinning. The mechanism of controlled release is based on buckling instability of the polymer shell under combined axial and radial compression, caused by volume changes of hydrogel responding to a specific stimulus. The device decouples releasable biomolecules from a hydrogel polymer matrix, avoiding chemical interactions between biomolecules and hydrogel polymer chains, and thus, alleviating nontrivial chemical and biological engineering design of hydrogel formulations. Temperature-sensitive hydrogel is used as a model hydrogel.

Published in:

Applied Physics Letters  (Volume:100 ,  Issue: 15 )

Date of Publication:

Apr 2012

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