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In this paper, the utilization of Zigbee as wireless sensor network (WSN) for medical application is demonstrated. The combination of various topologies is used to configure wireless sensors network to achieve high efficiency network architecture in medicine. The network consists of center coordinator, routers and sensor nodes. Mesh network is used for the connection between coordinator and router for range expansion. A performance of the proposed modality is tested in the normal situation. Besides, the architecture of the smart room systems is also proposed for healthcare monitoring. Physiological data and signal are transmitted using Xbee which is a wireless device operated in unlicensed radio frequency bands.