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In recent years, subthreshold operation has become a research focus for digital systems with limited energy budget (e.g. mobile, battery-powered devices, radio frequency identification (RFID), wireless sensor networks, or biomedical applications). Subthreshold operation allows for such low power consumption by reducing the supply voltage of the circuit below the threshold voltage of the transistors. As dynamic power depends quadratically on supply voltage, and static power depends exponentially on supply voltage, considerable power savings are achieved. At the same time propagation delays increase due to reduced transistor currents. Effectively, energy consumption per cycle can typically be reduced by a factor of 10 using subthreshold operation.