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Flow cytometry is an essential cell analysis technology in clinical immunology and haematology for the diagnosis and prognosis of disease. It involves the counting, identification and sorting of cells [1,2]. Conventional bulk measurements  require a large volume of blood, which is not desirable for the early detection of a disease, when only a very small percentage of cells contain evidence of the disease. In this paper, we propose, for the first time, a non-invasive and high-throughput single-cell analysis method using CMOS-integrated circuits in conjunction with a microfluidic channel as the first building block of a complete cell-sorting device.