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A CMOS impedance cytometer for 3D flowing single-cell real-time analysis with ΔΣ error correction

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6 Author(s)

Flow cytometry is an essential cell analysis technology in clinical immunology and haematology for the diagnosis and prognosis of disease. It involves the counting, identification and sorting of cells [1,2]. Conventional bulk measurements [3] require a large volume of blood, which is not desirable for the early detection of a disease, when only a very small percentage of cells contain evidence of the disease. In this paper, we propose, for the first time, a non-invasive and high-throughput single-cell analysis method using CMOS-integrated circuits in conjunction with a microfluidic channel as the first building block of a complete cell-sorting device.

Published in:

2012 IEEE International Solid-State Circuits Conference

Date of Conference:

19-23 Feb. 2012