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Transient Dynamics of Reduced-Order Models of Genetic Regulatory Networks

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2 Author(s)
Pal, R. ; Dept. of Electr. & Comput. Eng., Texas Tech Univ., Lubbock, TX, USA ; Bhattacharya, S.

In systems biology, a number of detailed genetic regulatory networks models have been proposed that are capable of modeling the fine-scale dynamics of gene expression. However, limitations on the type and sampling frequency of experimental data often prevent the parameter estimation of the detailed models. Furthermore, the high computational complexity involved in the simulation of a detailed model restricts its use. In such a scenario, reduced-order models capturing the coarse-scale behavior of the network are frequently applied. In this paper, we analyze the dynamics of a reduced-order Markov Chain model approximating a detailed Stochastic Master Equation model. Utilizing a reduction mapping that maintains the aggregated steady-state probability distribution of stochastic master equation models, we provide bounds on the deviation of the Markov Chain transient distribution from the transient aggregated distributions of the stochastic master equation model.

Published in:

Computational Biology and Bioinformatics, IEEE/ACM Transactions on  (Volume:9 ,  Issue: 4 )