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Novel energy-efficient modulation technique and circuits for transceivers operating in body sensor networks (BSNs) are described and investigated. They are obtained as a result of the development of differential binary phase shift keying (DBPSK) and named alternating quadratures DBPSK (AQ-DBPSK). While keeping the noise immunity and simplicity of synchronization and realization of DBPSK, AQ-DBPSK increases the efficiency of the transmitter power utilization by dB and radically improves tolerance to frequency offsets between the receivers and corresponding transmitters. The approach used in the development of AQ-DBPSK can also be used for developing novel spreading and despreading techniques and circuits.