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A MEMS-based approach to detection of single nucleotide polymorphisms for genetic disorder diagnosis

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6 Author(s)
Jing Zhu ; Dept. of Mech. Eng., Columbia Univ., New York, NY, USA ; Palla, M. ; Ronca, S. ; Warpner, R.
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This paper presents an integrated, MEMS-based approach to the detection of single nucleotide polymorphisms (SNPs). This SNP detection approach aims to eliminate complicated fluidic control operations by using a single-chamber microfluidic device, which incorporates polymerase chain reaction (PCR) and single base extension (SBE) on microbeads. Experimental results demonstrate that the device is capable of performing bead-based PCR, chemical elution, thermal elution, bead-based SBE, and on-chip desalting, which together potentially allow rapid, simple, accurate, multiplexed and highly efficient detection of SNPs.

Published in:

Micro Electro Mechanical Systems (MEMS), 2012 IEEE 25th International Conference on

Date of Conference:

Jan. 29 2012-Feb. 2 2012