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A study of the effects of non-specific filtering on the gene expression data prior to statistical testing

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1 Author(s)
Jiaxiu He ; Dept. of Preventive Med., Univ. of Southern California, Los Angeles, CA, USA

The overall variance filtering together with five different multiple testing procedures are examined using simulation studies. The results show that filtering do increase the power of detection without losing control of Type I error rates. The Benjamimi & Hochberg step-up procedure is the best among the five tested ones.

Published in:

Genomic Signal Processing and Statistics (GENSIPS), 2011 IEEE International Workshop on

Date of Conference:

4-6 Dec. 2011