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Mathematical modeling of macrophage activation in left ventricular remodeling post-myocardial infarction

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5 Author(s)
Yunji Wang ; Dept. of Electr. & Comput. Eng., Univ. of Texas at San Antonio, San Antonio, TX, USA ; Yufang Jin ; Yonggang Ma ; Halade, G.V.
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The macrophage plays a key role in regulating the remodeling of the left ventricle (LV) post-myocardial infarction (MI). However, the underlying regulatory mechanisms of macrophage activations were understudied. The goal of this study, therefore, was to establish a framework for macrophage activations and build a mathematical model based on the framework by integrating computational and experimental approaches. Accordingly, we established a framework including myocytes, monocytes, macrophages, and interlukin-1 (IL-1), IL-10, and tumor necrosis-alpha (TNF-α) based on literature, established a set of ordinary differential equations as the mathematical model, and primarily validated the model with experimental results. This study provides a useful tool to further study macrophage activations.

Published in:

Genomic Signal Processing and Statistics (GENSIPS), 2011 IEEE International Workshop on

Date of Conference:

4-6 Dec. 2011