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Assessing the efficacy of molecularly targeted agents by using Kalman filter

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4 Author(s)
Xiangfang Li ; GSP Lab., Texas A&M Univ., College Station, TX, USA ; Lijun Qian ; Bittner, M.L. ; Dougherty, E.R.

A novel preclinical model combining experimental methods and theoretical analysis is proposed to investigate the mechanism of action and identify pharmacodynamic characteristic of a drug. Instead of fixed time point analysis of the drug exposure to drug effect, the time course of drug effect for different doses are quantitatively studied on cell line-based platforms using Kalman filter, where tumor cells' responses to drugs through the use of fluorescent reporters are sampled frequently over a time-course. It is expected that such preclinical study will provide valuable suggestions about dosing regimens for in vivo experimental stage to increase productivity.

Published in:

Genomic Signal Processing and Statistics (GENSIPS), 2011 IEEE International Workshop on

Date of Conference:

4-6 Dec. 2011