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Low-Frequency Ultrasound in Medicine: An In Vivo Evaluation

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4 Author(s)
Fiorillo, A.S. ; Dept. of Health Sci., Magna Graecia Univ. of Catanzaro (UMG), Catanzaro, Italy ; Grimaldi, D. ; Paolino, D. ; Pullano, S.A.

Ultrasound energy at frequencies lower than 200 kHz has recently been used in the medical field to improve transdermal drug transport and to achieve a more suitable therapeutic approach. Low-frequency ultrasound energy was shown to be more effective than high-frequency ultrasound energy, so low-frequency ultrasound is attracting its share of attention in the medical field. In this paper, we take into consideration the most promising applications of low-frequency ultrasound with emphasis on transducer technology and measurements. In particular, a piezopolymer transducer is proposed, originally aimed at emulating the biosonar of bats, which has a low acoustic impedance in correspondence to biological tissue. The transducer is light, small, and inexpensive and could be used for medical applications, a possibility of which is a potential device for improving the cutaneous passage of drug compounds.

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Instrumentation and Measurement, IEEE Transactions on  (Volume:61 ,  Issue: 6 )