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A common view for the preferable positions of thwarting worm propagation is at the highly connected nodes. However, in certain conditions, such as when some popular users (highly connected nodes in the network) have more vigilance on the malicious codes, this may not always be the truth. In this letter, we propose a measure of betweenness and closeness to locate the most suitable positions for slowing down the worm propagation. This work provides practical values to the defense of topological worms.