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The main functions of the ITER gas injection system (GIS) are to provide gas fueling for plasma, wall conditioning operation, and neutral beam injectors. The dedicated manifold, which contains independent tubes for H2/D2, H2, T2, 4He/3He, N2/Ne, Ar, and evacuation, is the key part of the gas injection lines. It shall deliver gases from the tritium plant to various fueling systems. This paper presents an overview of the GIS manifold design, particularly introducing the solution of the penetration structure and the routing of the manifold from the concept design point of view.