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Aiming at diagnosing and preventing the cardiovascular disease, a portable ECG monitoring system based on Bluetooth mobile phones is presented. The system consists of some novel dry skin electrodes, an ECG monitoring circuit and a smart phone. The weak ECG signals extracted from the dry electrode can be amplified, band-pass filtered, analog-digital converted and so on. Finally it is sent to the mobile phone by Bluetooth technology for real-time display on screen. The core ECG monitoring circuit is composed of a CMOS preamplifier ASIC designed by ourselves, a band-pass filter, a microcontroller and a Bluetooth module. The volume is 5.5 cm × 3.4 cm × 1.6 cm, weight is only 20.76 g (without batteries), and power consumption is 115 mW. The tests show that the system can operate steadily, precisely and display the ECG in real time.