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Assessment of the lung mechanics is crucial in lung function studies. Commonly lung mechanics is achieved through measurement of the input impedance of the lung where the experimental data is ideal for the application of system identification techniques. This study proposes a new approach for investigating the severity of lung conditions and also evaluating the treatment progression. The proposed method is established based on linear parametric identification of lung input impedance in mice and is applied to normal and asthmatic models (including acute, tolerant and chronic asthma) as well as a pharmacological intervention model. Experimental findings confirm the effectiveness of the analysis technique applied here. We discuss the potential application of this method to analyses of human lung mechanics.