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Comprehensive investigation of connectivity map data-towards a drug mode of action network for personalized thnerapy

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4 Author(s)
Chifeng Ma ; Dept. of ECE, Univ. of Texas at San Antonio, San Antonio, TX, USA ; Harry, H.-I. ; Yufei Huang ; Yidong Chen

This work aims at addressing the problems existed in the original cMap algorithm and proposed a new drug Mode-of Action Network construction scheme including data pre-processing, signature gene extraction, network construction and query prediction. Multiple analyses were conducted to investigate the structure of constructed drug mode-of-action network and the cMap based Mode-of-Action network is tested on the independent drug treatment datasets. All result shows our cMap based drug Mode-of-Action network is both statistically and biologically significant and out-perform the original cMap project.

Published in:

Bioinformatics and Biomedicine Workshops (BIBMW), 2011 IEEE International Conference on

Date of Conference:

12-15 Nov. 2011