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Electrophysiological mechanisms involved in the electrical stimulation of fracture healing remain largely unknown. The purpose of this study was to establish relationships between osteogenetic response and intraosseous measures of electrical dose in experimental fractures (osteotomies) of canine radii stimulated by direct currents. The response was determined postmortem at seven weeks after osteotomy by measuring the bending rigidity and four physicochemical properties; tissue density, mineral density, matrix density, and mineral-to-matrix ratio. The currents measured in bone ranged from 0.1 to 17.0 mu A. Three regions of enhanced osteogenetic response were observed at approximately 1, 7, and 13 mu A, separated by regions of unstimulated response. Evidence suggests that enhanced response resulted mainly from electrical modulation of early events in the fracture repair sequence.