By Topic

A visual navigation system for querying neural stem cell imaging data

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

4 Author(s)
Kulkarni, I. ; Dept. of Comput. Sci., Univ. of California, Irvine, CA, USA ; Mistry, S.Y. ; Cummings, B. ; Gopi, M.

Cellular biology deals with studying the behavior of cells. Current time-lapse imaging microscopes help us capture the progress of experiments at intervals that allow for understanding of the dynamic and kinematic behavior of the cells. On the other hand, these devices generate such massive amounts of data (250GB of data per experiment) that manual sieving of data to identify interesting patterns becomes virtually impossible. In this paper we propose an end-to-end system to analyze time-lapse images of the cultures of human neural stem cells (hNSC), that includes an image processing system to analyze the images to extract all the relevant geometric and statistical features within and between images, a database management system to manage and handle queries on the data, a visual analytic system to navigate through the data, and a visual query system to explore different relationships and correlations between the parameters. In each stage of the pipeline we make novel algorithmic and conceptual contributions, and the entire system design is motivated by many different yet unanswered exploratory questions pursued by our neurobiologist collaborators. With a few examples we show how such abstract biological queries can be analyzed and answered by our system.

Published in:

Visual Analytics Science and Technology (VAST), 2011 IEEE Conference on

Date of Conference:

23-28 Oct. 2011